Peptidoglycan Recognition Protein 1 (PGLYRP1) an early indicator of infection by B. burgdoferi
There's a new way to diagnose and treat Lyme Disease infection. This is because a protein that protects host from infection has been discovered.
Lyme disease is a vector-borne endemic disease of North America and is transmitted by ticks which have been infected by Borrelia burgdorferi. Its etiology varies from host to host, most infected individuals experience mild treatable symptoms. Infection from Lyme disease can spread to infect the heart, joints, nervous system, and other organs if untreated.
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A study conducted and published in PLOS ONE expressed more than 1,000 human genes in yeast and analyzed their interactions with 36 Borrelia burgdorferi samples. The finding were that one protein, Peptidoglycan Recognition Protein 1 (PGLYRP1) behaves in a manner similar to an early indicator of infection by B. burgdoferi to notify the immune system. Mice lacking PGLYRP1 expressed higher concentrations of the bacteria when exposed to Lyme Disease this was compared against Mice that contained this gene. Thus serving as an indicator of immune system dysfunction.
The pathway for improving ability to fight this infection involved stimulation of production of the PGLYRP1 gene.